Design and Analysis of Cancer Control Studies Using the Sas System
نویسندگان
چکیده
This paper focuses on the details of study design, data elements and analytical methods necessary for oncology clinical trials when the primary endpoint involves symptom control rather than treatment outcome. We will present work carried out on previous North Central Cancer Treatment Group (NCCTG) Cancer Control (CC) clinical trials which involved standard and novel results which were obtainable via SAS code. Measurement issues with respect to pain, stomatitis, and other quality of life related endpoints will be highlighted. Considerations involved in determining clinical significance, and related power calculations, for these types of endpoints will be presented.
منابع مشابه
The Beneficial Effects of Fiber on Major Chronic Diseases: A Review of Evidence
Background: Fiber is a carbohydrate, which is neither completely digested nor absorbed in the small intestine, but may be fermented and plays a key role in the human health. We investigated the beneficial effects of fiber on major chronic diseases. Methods: It was extracted the relevant articles by searching the PubMed, ScienceDirect, and Scopus databases using the following keywords: dietary f...
متن کاملReceptor Tyrosine Kinase Inhibitory Activities and Molecular Docking Studies of Some Pyrrolo[2,3-d]pyrimidine Derivatives
In this study, we aimed to determine VEGFR-2, EGFR and PDGFR-β tyrosine kinase inhibitory activities of some pyrrolo[2,3-d]pyrimidine derivatives previously synthesized and showed potent cytotoxic and apoptotic effects against several cancer cell lines by our group and to evaluate the relationships between inhibitory activities and binding properties of the active compounds by molecular docking...
متن کاملبرآورد اثر متقابل ژن - محیط در سرطان پستان با مطالعات مورد - شاهد و فقط مورد
Background and Aim: Limitations of the traditional methods for assessing G*E interaction- including case-control studies- led to development of several non-traditional approaches. This study aims to assess the interaction between the genetic background (history of breast cancer in first degree relatives) and environmental influences (reproductive/menstrual factors) in patients with breast cance...
متن کاملA New Robust Control Design Based on Feedback Compensator for Sssc
In this paper, the modified linearized Phillips-Heffron model is utilized to theoretically analyze asingle-machine infinite-bus (SMIB) installed with SSSC. Then, the results of this analysis are used forassessing the potential of an SSSC supplementary controller to improve the dynamic stability of apower system. This is carried out by measuring the electromechanical controllability through sing...
متن کاملReinforcement learning based feedback control of tumor growth by limiting maximum chemo-drug dose using fuzzy logic
In this paper, a model-free reinforcement learning-based controller is designed to extract a treatment protocol because the design of a model-based controller is complex due to the highly nonlinear dynamics of cancer. The Q-learning algorithm is used to develop an optimal controller for cancer chemotherapy drug dosing. In the Q-learning algorithm, each entry of the Q-table is updated using data...
متن کامل